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Whipple’s Triad

Whipple’s triad

Whipple’s Triad is a triad of symptoms suggestive of hypoglycemia.

It includes:

  • Spontaneous hypoglycemia with blood sugar levels less than 50mg/100ml
  • CNS or vasomotor symptoms that may range from excessive sweating, dizziness, syncope to odd behavior and seizures
  • Relief of symptoms by oral or intravenous administration of glucose.


Chronic hypoglycemia leads to attenuated autonomic response. Therefore, it may present with CNS symptoms due to neuroglycopenia (neuro-nerve; glyco- glucose; penia- deficiency).

Symptoms occurring while fasting or following exercise are more likely to be pathological than post-prandial-reactive hypoglycemia.

Reactive hypoglycemia/ postprandial hypoglycemia- recurrent episodes of hypoglycemia occurring within 4 hours post meal. It is thought to be due to an excessive release of insulin after a carbohydrate dense meal, the levels of which remain high even after digestion.

*Always consider hypoglycemia in all comatose patients even in apparently obvious cases like hemiplegic stroke or alcohol intoxication.

Causes that may present as Whipple’s triad:


Dr.Harpreet Singh MD, FACP is a Chief Executive Officer and Founder of Vital Checklist and The text, graphics, images, videos and other material contained in the videos and iCrush Website ("Content") are for informational purposes only. The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.
Himanshu Deshwal- Assistant Editor
Dr. Himanshu Deshwal is a fresh graduate out of a reputed medical school in India, the Armed Forces Medical College, Pune. Dr. Deshwal is an active researcher constantly on the look out for projects that may help him hone his talents and abilities to the next level. Being an active sportsman he understands the importance of a holistic approach to healthcare and wellbeing. He has been a keen advocate of following an active lifestyle in midst of our busy lives.

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